Coronavirus-induced autoimmunity

Mercury-induced autoimmunity in mice.

We have studied the effect of gender, genetics, and toxicokinetics on immune parameters in mercury-induced autoimmunity in mice. Data strongly suggest that the mechanism for mercury-induced autoimmunity involves modification of the autoantigen fibrillarin by mercury followed by a T-cell-dependent immune response driven by the modified fibrillarin. Mice with different H-2 haplotypes were treated...

Mercury-induced Autoimmunity: Genetics and Immunoregulation

Autoimmunity induced in rabbits by rinderpest virus.

During rinderpest virus infection in rabbits, 19S cold hemagglutinating antibody against rabbit erythrocytes and 7S anti-nuclear antibody, which reacts with the nuclei and/or the nuclear membranes in immunofluorescent staining, were demonstrated. Virus infection that affected the thymus-dependent immune functions was speculated to act as a trigger for the production of these two autoantibodies.

Asbestos-induced autoimmunity in C57BL/6 mice.

Environmental impacts on autoimmunity have significant public health implications. Epidemiological studies have shown associations between exposure to airborne silicates, such as crystalline silica or asbestos, and autoimmunity, but the etiology remains unclear. The purpose of this study was to test the hypothesis that asbestos could lead to a specific pattern of autoantibodies and pathology in...

Autoimmunity Induced by Hydrocarbon Oils in Mice

For many decades, mineral oils with or without dried mycobacteria, i.e. Complete and Incomplete Freund ́s Adjuvant, have been the most commonly used immune adjuvants for experimental work. Later on, better defined hydrocarbon oils such as pristane (2,6,10,14-tetramethylpentadecane), squalene (2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosa-hexane), or hexadecane have emerged and partially r...